John A Kellum Selected Research

Insulin-Like Growth Factor Binding Proteins

10/2021	Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.
1/2021	Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection.
11/2020	Serial Measurement of Cell-Cycle Arrest Biomarkers [TIMP-2] · [IGFBP7] and Risk for Progression to Death, Dialysis, or Severe Acute Kidney Injury in Patients with Septic Shock.
1/2020	Effects of Different Doses of Remote Ischemic Preconditioning on Kidney Damage Among Patients Undergoing Cardiac Surgery: A Single-Center Mechanistic Randomized Controlled Trial.
11/2019	Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury.
1/2019	Associations of Perioperative Renal Oximetry Via Near-Infrared Spectroscopy, Urinary Biomarkers, and Postoperative Acute Kidney Injury in Infants After Congenital Heart Surgery: Should Creatinine Continue to Be the Gold Standard?
1/2019	Serial Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 and the Prognosis for Acute Kidney Injury over the Course of Critical Illness.
1/2018	Kinetics of Urinary Cell Cycle Arrest Markers for Acute Kidney Injury Following Exposure to Potential Renal Insults.
8/2017	Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery.
2/2017	Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells.

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John A Kellum Research Topics

Disease

173	Acute Kidney Injury (Acute Renal Failure) 10/2022 - 01/2002
100	Sepsis (Septicemia) 07/2022 - 02/2002
80	Critical Illness (Critically Ill) 10/2022 - 01/2002
29	Inflammation (Inflammations) 01/2021 - 01/2003
25	Kidney Diseases (Kidney Disease) 11/2022 - 03/2013
25	Septic Shock (Toxic Shock Syndrome) 02/2022 - 02/2002
17	Infections 01/2022 - 08/2007
14	Pneumonia (Pneumonitis) 01/2022 - 04/2007
14	Acidosis 07/2020 - 02/2002
10	Renal Insufficiency (Renal Failure) 01/2021 - 08/2003
10	Heart Failure 10/2020 - 10/2002
8	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 01/2003
8	Hypotension (Low Blood Pressure) 08/2021 - 01/2004
8	Oliguria 10/2019 - 04/2008
7	Fibrosis (Cirrhosis) 01/2022 - 01/2010
7	Brain Death (Brain Dead) 01/2019 - 01/2004
6	COVID-19 01/2022 - 10/2020
5	Reperfusion Injury 06/2022 - 07/2010
5	Acute Disease 01/2022 - 01/2016
5	Drug-Related Side Effects and Adverse Reactions 12/2021 - 10/2014
5	Hemorrhage 10/2020 - 09/2007
4	Ischemia 10/2021 - 01/2010
4	Chronic Renal Insufficiency 01/2021 - 01/2010
4	Multiple Organ Failure (MODS) 12/2019 - 10/2002
4	Shock 01/2017 - 06/2002
3	Thrombocytopenia (Thrombopenia) 12/2019 - 10/2002
3	Azotemia 10/2019 - 01/2016
3	Hypercapnia 10/2019 - 05/2007
3	Body Weight (Weight, Body) 01/2018 - 07/2008
3	Peritonitis 08/2017 - 12/2012
3	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 10/2013 - 01/2003

Drug/Important Bio-Agent (IBA)

77	Biomarkers (Surrogate Marker)IBA 10/2022 - 12/2005
49	CreatinineIBA 01/2022 - 12/2005
25	CytokinesIBA 01/2020 - 12/2002
18	Insulin-Like Growth Factor Binding ProteinsIBA 10/2021 - 01/2014
18	Interleukin-6 (Interleukin 6)IBA 01/2019 - 01/2004
11	Pharmaceutical PreparationsIBA 01/2022 - 10/2002
10	AcidsIBA 01/2019 - 02/2002
10	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2017 - 01/2004
9	Lactic Acid (Lactate)FDA LinkGeneric 09/2019 - 05/2004
9	Interleukin-10 (Interleukin 10)IBA 10/2014 - 01/2004
8	Biological ProductsIBA 10/2022 - 04/2007
8	Tissue Inhibitor of MetalloproteinasesIBA 10/2021 - 04/2014
8	Tissue Inhibitor of Metalloproteinase-2IBA 11/2020 - 01/2014
8	Anti-Bacterial Agents (Antibiotics)IBA 11/2019 - 02/2012
7	Saline SolutionIBA 08/2021 - 02/2002
7	AlbuminsIBA 01/2021 - 01/2007
7	DiureticsIBA 10/2020 - 08/2004
7	ElectrolytesIBA 01/2016 - 02/2002
6	Aluminum Oxide (Sapphire)IBA 10/2021 - 02/2013
6	SolutionsIBA 08/2021 - 02/2002
6	ChloridesIBA 01/2019 - 02/2006
6	fibrin fragment D (D-dimer)IBA 01/2019 - 05/2009
6	ProcalcitoninIBA 07/2018 - 07/2008
6	Urea (Carbamide)FDA LinkGeneric 07/2014 - 09/2008
5	Folic Acid (Vitamin M)FDA LinkGeneric 06/2022 - 09/2011
5	SodiumIBA 01/2021 - 01/2010
5	Vancomycin FDA LinkGeneric 11/2019 - 06/2015
5	Bicarbonates (Hydrogen Carbonate)IBA 09/2019 - 03/2015
5	Lipocalin-2IBA 01/2019 - 09/2011
4	Proteins (Proteins, Gene)FDA Link 06/2022 - 01/2003
4	Carrier Proteins (Binding Protein)IBA 01/2021 - 01/2018
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2021 - 10/2014
4	AntithrombinsIBA 09/2012 - 10/2010
3	EndotoxinsIBA 07/2022 - 05/2018
3	IronIBA 06/2022 - 01/2019
3	LipopolysaccharidesIBA 06/2022 - 12/2002
3	Phosphates (Orthophosphate)IBA 06/2022 - 10/2009
3	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2022 - 02/2014
3	ChemokinesIBA 03/2021 - 07/2014
3	Insulin (Novolin)FDA Link 01/2021 - 01/2018
3	Heparin (Liquaemin)FDA LinkGeneric 10/2020 - 01/2011
3	Citric Acid (Citrate)FDA LinkGeneric 10/2020 - 09/2007
3	Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric 11/2019 - 05/2019
3	Crystalloid SolutionsIBA 01/2019 - 06/2017
3	Polymyxin B (Aerosporin)FDA LinkGeneric 10/2018 - 01/2007
3	salicylhydroxamic acid (SHAM)IBA 06/2015 - 12/2012
3	InterleukinsIBA 10/2014 - 01/2004
3	PlacebosIBA 07/2014 - 08/2012
3	NF-kappa B (NF-kB)IBA 08/2012 - 03/2004

Therapy/Procedure

64	Renal Replacement Therapy (Therapies, Renal Replacement) 11/2022 - 11/2002
62	Therapeutics 04/2022 - 01/2002
23	Continuous Renal Replacement Therapy 01/2022 - 01/2002
22	Resuscitation 02/2021 - 02/2002
13	Critical Care (Surgical Intensive Care) 10/2022 - 06/2002
12	Renal Dialysis (Hemodialysis) 10/2020 - 01/2002
11	Artificial Respiration (Mechanical Ventilation) 08/2021 - 08/2005
10	Punctures 01/2022 - 01/2004
10	Ligation 01/2022 - 01/2004
9	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2020 - 10/2002
6	Liver Transplantation 01/2020 - 07/2010
6	Length of Stay 01/2019 - 01/2006
6	Early Goal-Directed Therapy 01/2019 - 04/2008
6	Hemofiltration 01/2016 - 02/2002
4	Fluid Therapy (Oral Rehydration Therapy) 01/2019 - 12/2002
4	Transplantation 08/2009 - 01/2004
3	Precision Medicine 04/2021 - 10/2017
3	Blood Transfusion (Blood Transfusions) 01/2019 - 05/2012
3	Hemoperfusion 10/2018 - 01/2007
3	Intermittent Renal Replacement Therapy 01/2018 - 01/2010